

ABSTRACT

The present invention relates to new compounds having anti-hypertensive effect, which compounds are of the formulawherein R&lt;sup&gt;1&lt;/sup&gt; is selected from the group consisting of -CH&lt;sub&gt;1&lt;/sub&gt;, -C&lt;sub&gt;2&lt;/sub&gt;H&lt;sub&gt;5&lt;/sub&gt;, -CH&lt;sub&gt;2&lt;/sub&gt;CH&lt;sub&gt;2&lt;/sub&gt;OCH&lt;sub&gt;3&lt;/sub&gt;, - CH&lt;sub&gt;2&lt;/sub&gt;CH&lt;sub&gt;2&lt;/sub&gt;OC&lt;sub&gt;2&lt;/sub&gt;H&lt;sub&gt;5&lt;/sub&gt;, and (CH&lt;sub&gt;2&lt;/sub&gt;CH&lt;sub&gt;2&lt;/sub&gt;O)&lt;sub&gt;2&lt;/sub&gt;CH&lt;sub&gt;3&lt;/sub&gt;, and R&lt;sup&gt;2&lt;/sup&gt; is selected from the group consisting of -C&lt;sub&gt;2&lt;/sub&gt;H&lt;sub&gt;3&lt;/sub&gt;, -CH(CH&lt;sub&gt;3&lt;/sub&gt;)&lt;sub&gt;2&lt;/sub&gt;, -C(CH&lt;sub&gt;3&lt;/sub&gt;)&lt;sub&gt;3&lt;/sub&gt;, -CH(CH&lt;sub&gt;1&lt;/sub&gt;)C&lt;sub&gt;2&lt;/sub&gt;H&lt;sub&gt;3&lt;/sub&gt;, -CH&lt;sub&gt;2&lt;/sub&gt;CH&lt;sub&gt;2&lt;/sub&gt;OCH(CH&lt;sub&gt;3&lt;/sub&gt;)&lt;sub&gt;2&lt;/sub&gt;, -CH(CH&lt;sub&gt;3&lt;/sub&gt;)CH&lt;sub&gt;2&lt;/sub&gt;OCH&lt;sub&gt;3&lt;/sub&gt;, C(CH&lt;sub&gt;3&lt;/sub&gt;)&lt;sub&gt;2&lt;/sub&gt;CH&lt;sub&gt;2&lt;/sub&gt;OCH&lt;sub&gt;3&lt;/sub&gt;, -CH&lt;sub&gt;2&lt;/sub&gt;C=CH, and -CH&lt;sub&gt;2&lt;/sub&gt;C(CH&lt;sub&gt;3&lt;/sub&gt;)=CH&lt;sub&gt;2&lt;/sub&gt;, whereby R&#39; and R are not the same, R&#39; is selected from the group consisting of chloro and methoxy, and R&#39; is selected from the group consisting of chloro, methyl, and methoxy, process for the preparation of said compounds, and pharmaceutical preparations containing said compounds.



